A vulnerability in the prompt-based persona conditioning of clinical Large Language Models (LLMs) allows system-level role prompts (e.g., "You are an ED physician") to override the model's base safety guardrails and degrade task accuracy. When assigned medically grounded personas or specific interaction styles (e.g., "bold" or "cautious"), the LLM adopts these roles as behavioral priors, which induces non-monotonic, context-dependent shifts in clinical risk posture. While improving performance…
Source: arXiv